S Tier
Dead Branch
rare
Whenever you Exhaust a card, add a random card to your hand.
S+
Singing Bowl
common
When adding cards to your deck, you may gain +2 Max HP instead.
S
Tungsten Rod
rare
Whenever you would lose HP, lose 1 less.
S
A Tier
Orichalcum
common
If you end your turn without Block, gain 6 Block.
A+
Vajra
common
At the start of each combat, gain 1 Strength.
A+
Necronomicon
event
The first Attack played each turn that costs 2 or more is played twice. When you take this relic, become Cursed.
A+
Busted Crown
boss
Gain 1 Energy at the start of each turn. On Card Reward screens, you have 2 fewer cards to choose from.
A+
Mark of Pain
boss
Gain 1 Energy at the start of each turn. Start combats with 2 Wounds in your draw pile.
A+
Bag of Marbles
common
At the start of each combat, apply 1 Vulnerable to ALL enemies.
A
Pen Nib
common
Every 10th Attack you play deals double damage.
A
Cursed Key
boss
Gain 1 Energy at the start of each turn. Whenever you open a non-boss chest, obtain a Curse.
A
Snecko Eye
boss
Draw 2 additional cards each turn. Start each combat Confused.
A
Sozu
boss
Gain 1 Energy at the start of each turn. You can no longer use potions.
A
Velvet Choker
boss
Gain 1 Energy at the start of each turn. You cannot play more than 6 cards per turn.
A
Fusion Hammer
boss
Gain 1 Energy at the start of each turn. You can no longer Smith at Rest Sites.
A
Incense Burner
rare
Every 6 turns, gain 1 Intangible.
A
Burning Blood
starter
At the end of combat, heal 6 HP.
A
Paper Phrog
uncommon
Enemies with Vulnerable take 75% more damage rather than 50%.
A
Regal Pillow
common
Heal an additional 15 HP when you Rest.
A-
Meat on the Bone
uncommon
If your HP is at or below 50% at the end of combat, heal 12 HP.
A-
Molten Egg
uncommon
Whenever you add an Attack card to your deck, it is Upgraded.
A-
Shuriken
uncommon
Every time you play 3 Attacks in a single turn, gain 1 Strength.
A-
Toxic Egg
uncommon
Whenever you add a Skill card to your deck, it is Upgraded.
A-
Gambling Chip
rare
At the start of each combat, discard any number of cards then draw that many.
A-
Thread and Needle
rare
At the start of each combat, gain 4 Plated Armor.
A-
Ectoplasm
boss
Gain 1 Energy at the start of each turn. You can no longer gain Gold.
A-
Runic Pyramid
boss
At the end of your turn, you no longer discard your hand.
A-
Girya
rare
You can now gain Strength at Rest Sites. (3 times max)
A-
B Tier
Anchor
common
Start each combat with 10 Block.
B+
Lantern
common
Gain 1 Energy on the first turn of each combat.
B+
Bottled Flame
uncommon
Upon pick up, choose an Attack card. At the start of each combat, this card will be in your hand.
B+
Bottled Lightning
uncommon
Upon pick up, choose a Skill card. At the start of each combat, this card will be in your hand.
B+
Bottled Tornado
uncommon
Upon pick up, choose a Power card. At the start of each combat, this card will be in your hand.
B+
Frozen Egg
uncommon
Whenever you add a Power card to your deck, Upgrade it.
B+
Gremlin Horn
uncommon
Whenever an enemy dies, gain 1 Energy and draw 1 card.
B+
Runic Dome
boss
Gain 1 Energy at the start of each turn. You can no longer see enemy Intents.
B+
Strange Spoon
shop
Cards which Exhaust when played will instead discard 50% of the time.
B+
See AlsoSlay the Spire Tier List - Dominate the Spire with the Best Boss Relics in the Game - Avid AchieversSlay the Spire Tier List - Dominate the Spire with the Best Boss Relics in the Game - Avid AchieversSlay the Spire: Fundorte aller Relikte und was sie bringenSlay the Spire relics - the worst and the bestCoffee Dripper
boss
Gain 1 Energy at the start of each turn. You can no longer Rest at Rest Sites.
B+
Chemical X
shop
The effects of your cost X cards are increased by 2.
B+
Runic Cube
uncommon
Whenever you lose HP, draw 1 card.
B+
Charon's Ashes
rare
Whenever you Exhaust a card, deal 3 damage to ALL enemies.
B+
Magic Flower
rare
Healing is 50% more effective during combat.
B+
Horn Cleat
uncommon
At the start of your 2nd turn, gain 14 Block.
B+
Captain's Wheel
rare
At the start of your 3rd turn, gain 18 Block.
B+
Fossilized Helix
rare
Prevent the first time you would lose HP each combat.
B+
Bag of Preparation
common
At the start of each combat, draw 2 additional cards.
B
Juzu Bracelet
common
Regular enemy combats are no longer encountered in ? rooms.
B
Oddly Smooth Stone
common
At the start of each combat, gain 1 Dexterity.
B
Centennial Puzzle
uncommon
The first time you lose HP each combat, draw 3 cards.
B
Pear
uncommon
Raise your Max HP by 10.
B
Ginger
rare
You can no longer become Weakened.
B
Eternal Feather
uncommon
For every 5 cards in your deck, heal 3 HP whenever you enter a Rest Site.
B
Lizard Tail
rare
When you would die, heal to 50% of your Max HP instead (works once).
B
Philosopher's Stone
boss
Gain 1 Energy at the start of each turn. ALL enemies start with 1 Strength.
B
White Beast Statue
uncommon
Potions always drop after combat.
B
Nilry's Codex
event
At the end of each turn, you can choose 1 of 3 random cards to shuffle into your draw pile.
B
Face of Cleric
event
Raise your Max HP by 1 after each combat.
B
Clockwork Souvenir
shop
At the start of each combat, gain 1 Artifact.
B
Sacred Bark
boss
Double the effectiveness of potions.
B
Mummified Hand
uncommon
Whenever you play a Power, a random card in your hand costs 0 for the turn.
B-
Pantograph
uncommon
At the start of boss combats, heal 25 HP.
B-
Bird-Faced Urn
rare
Whenever you play a Power, heal 2 HP.
B-
Du-Vu Doll
rare
For each Curse in your deck, start each combat with 1 additional Strength.
B-
Ice Cream
rare
Energy is now conserved between turns.
B-
Mango
rare
Raise your Max HP by 14.
B-
Black Star
boss
Elites now drop 2 Relics when defeated.
B-
Bloody Idol
event
Whenever you gain Gold, heal 5 HP.
B-
Enchiridion
event
At the start of each combat, add a random Power card to your hand. It costs 0 until the end of turn.
B-
Red Mask
event
At the start of each combat, apply 1 Weak to ALL enemies.
B-
Medical Kit
shop
Status cards can now be played. Playing a Status will Exhaust the card.
B-
Turnip
rare
You can no longer become Frail.
B-
Nunchaku
rare
Every time you play 10 Attacks, gain 1 Energy.
B-
Dolly's Mirror
shop
Upon pickup, obtain an additional copy of a card in your deck.
Champion Belt
rare
Whenever you apply Vulnerable, also apply 1 Weak.
B-
Slaver's Collar
boss
During Boss and Elite combats, gain [energy] at the start of your turn.
B-
Preserved Insect
common
Enemies in Elite combats have 25% less HP.
B-
C Tier
Whetstone
common
Upon pick up, Upgrade 2 random Attacks.
C+
Kunai
uncommon
Every time you play 3 Attacks in a single turn, gain 1 Dexterity.
C+
Astrolabe
boss
Upon pickup, choose and Transform 3 cards, then Upgrade them.
C+
Calling Bell
boss
Upon pickup, obtain an unremoveable Curse and 3 relics.
C+
Golden Idol
event
Enemies drop 25% more Gold.
C+
Hand Drill
shop
Whenever you break an enemy's Block, apply 2 Vulnerable.
C+
Pocketwatch
rare
Whenever you play 3 or less cards in a turn, draw 3 additional cards at the start of your next turn.
C+
Black Blood
boss
Replaces Burning Blood. At the end of combat, heal 12 HP.
C+
Akabeko
common
Your first Attack each combat deals 8 additional damage.
C+
Ancient Tea Set
common
Whenever you enter a Rest Site, start the next combat with 2 Energy.
C
Happy Flower
common
Every 3 turns, gain 1 Energy.
C
Strawberry
common
Raise your Max HP by 7.
C
Tiny Chest
common
Every 4th '?' room is a Treasure room.
C
War Paint
common
Upon pick up, Upgrade 2 random Skills.
C
Mercury Hourglass
uncommon
At the start of your turn, deal 3 damage to ALL enemies.
C
Frozen Eye
rare
When viewing your Draw Pile, the cards are now shown in order.
C
Peace Pipe
rare
You can now remove cards from your deck at Rest Sites.
C
Orrery
shop
Choose and add 5 cards to your deck.
C
Question Card
uncommon
On Card Reward screens, choose from 4 cards instead of 3.
C
Potion Belt
common
Upon pick up, gain 2 Potion slots.
C
Meal Ticket
shop
Whenever you enter a shop room, heal 15 hp.
C
Red Skull
rare
While your HP is at or below 50%, you have 3 additional Strength.
C
Blood Vial
common
At the start of each combat, heal 2 HP.
C-
Blue Candle
uncommon
Curse cards can now be played. Playing a Curse will make you lose 1 HP and Exhausts the card.
C-
Ornamental Fan
uncommon
Every time you play 3 Attacks in a single turn, gain 4 Block.
C-
Smiling Mask
uncommon
The merchant's card removal service now always costs 50 Gold.
C-
Toolbox
uncommon
At the start of each combat, add a random colorless card to your hand.
C-
Old Coin
rare
Gain 300 Gold.
C-
Shovel
rare
You can now Dig for loot at Rest Sites.
C-
Torii
rare
Whenever you would receive 5 or less unblocked Attack damage, reduce it to 1.
C-
Tiny House
boss
Obtain 1 potion. Gain 30 Gold. Raise your Max HP by 5. Obtain 1 card. Upgrade 1 Random card.
C-
Nloth's Gift
event
Triples the chance of receiving rare cards as monster rewards.
C-
Odd Mushroom
event
When Vulnerable, take 25% more damage rather than 50%.
C-
Toy Ornithopter
shop
Whenever you use a potion, heal 5 HP.
C-
Sling of Courage
shop
Start each Elite combat with 2 Strength.
C-
D Tier
Bronze Scales
common
Start each combat with 3 Thorns.
D+
Prayer Wheel
common
Normal enemies drop an additional card reward.
D+
Darkstone Periapt
uncommon
Whenever you obtain a Curse, increase your Max HP by 6.
D+
Matryoshka
uncommon
The next 2 chests you open contain 2 Relics. (Excludes boss chests)
D+
The Courier
uncommon
The merchant no longer runs out of cards, relics, or potions and his prices are reduced by 20%.
D+
Sundial
rare
Every 3 times you shuffle your deck, gain 2 Energy.
D+
Pandora's Box
boss
Transform all Strikes and Defends.
D+
Lee's Waffle
shop
Raise your Max HP by 7 and heal all of your HP.
D+
Membership Card
shop
50% discount on all products!
D+
Empty Cage
boss
Upon pick up, remove 2 cards from your deck.
D+
Ssserpent Head
event
Whenever you begin an Event, gain 50 Gold.
D+
The Abacus
shop
Gain 6 Block whenever you shuffle your draw pile.
D+
Self-Forming Clay
uncommon
Whenever you lose HP in combat, gain 3 Block next turn.
D+
Brimstone
shop
At the start of your turn, gain 2 Strength and ALL enemies gain 1 Strength.
D+
Strike Dummy
uncommon
Cards containing "Strike" deal 3 additional damage.
D+
Art of War
common
If you do not play any Attacks during your turn, gain an extra Energy next turn.
D
Omamori
common
Negate the next 2 Curses you obtain.
D
Letter Opener
uncommon
Every time you play 3 Skills in a single turn, deal 5 damage to ALL enemies.
D
Runic Dodecahedron
uncommon
If your HP is full, gain 1 Energy at the start of each turn.
D
Calipers
rare
At the start of your turn, lose 15 Block rather than all of your Block.
D
Orange Pellets
shop
Whenever you play a Power, Attack, and Skill in the same turn, remove all of your Debuffs.
D
Maw Bank
common
Whenever you climb a floor, gain 12 Gold. No longer works when you spend any Gold at the shop.
D
Stone Calendar
rare
At the end of turn 7, deal 52 damage to ALL enemies.
D
Ceramic Fish
common
Whenever you add a card to your deck, gain 9 Gold.
D
Ink Bottle
uncommon
Whenever you play 10 cards, draw 1 card.
D
Dream Catcher
common
Whenever you rest, you may add a card to your deck.
D-
Unceasing Top
rare
Whenever you have no cards in hand during your turn, draw a card.
D-
Neow's Lament
event
Enemies in your first 3 combats will have 1 HP.
D-
The Boot
common
Whenever you would deal 4 or less unblocked Attack damage, increase it to 5.
D-
E Tier
Cauldron
shop
When obtained, brews 5 random potions.
E
F Tier
Spirit Poop
event
It's unpleasant.
F
Mark of the Bloom
event
You can no longer gain health.
F
N'Loth's Hungry Face
event
The next non-boss chest you open is empty.
F
Gremlin Visage
event
Start each combat with 1 Weak.
F
Cultist Headpice
event
You feel more talkative (no effect).
F